Decrease in NMDA receptor-signalling activity in the anterior cingulate cortex diminishes defensive behaviour and unconditioned fear-induced antinociception elicited by GABAergic tonic inhibition impairment in the posterior hypothalamus.
Panicolytic-like effects caused by substantia nigra pars reticulata pretreatment with low doses of endomorphin-1 and high doses of CTOP or the NOP receptors antagonist JTC-801 in male Rattus norvegicus.
Psychopharmacology (Berl). 2017 Aug 30
da Silva JA, Biagioni AF, Almada RC, de Freitas RL, Coimbra NC
5-Hydroxytryptamine 2A receptors of the dorsal raphe nucleus modulate panic-like behaviours and mediate fear-induced antinociception elicited by neuronal activation in the central nucleus of the inferior colliculus.
Behav Brain Res. 2017 Jul 21
da Silva Soares R Jr, Falconi-Sobrinho LL, Dos Anjos-Garcia T, Coimbra NC
Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests.
Rev Bras Psiquiatr. 2017 Jan-Mar;39(1):72-83
Coimbra NC, Paschoalin-Maurin T, Bassi GS, Kanashiro A, Biagioni AF, Felippotti TT, Elias-Filho DH, Mendes-Gomes J, Cysne-Coimbra JP, Almada RC, Lobão-Soares B.
Connexions between the dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal grey matter are critical in the elaboration of hypothalamically mediated panic-like behaviour.
Neuroethological validation of an experimental apparatus to evaluate oriented and non-oriented escape behaviours: Comparison between the polygonal arena with a burrow and the circular enclosure of an open-field test
Behav Brain Res. 2015 Nov 3;298(Pt B):65-77
Biagioni AF, Anjos-Garcia TD, Ullah F, Fisher IR, Falconi-Sobrinho LL, Freitas RL, Felippotti TT, Coimbra NC
Relevance of dorsomedial hypothalamus, dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal gray matter in the organization of freezing or oriented and non-oriented escape emotional behaviors
Behav Brain Res. 2015 Oct 15;293:143-52
Ullah F, dos Anjos-Garcia T, dos Santos IR, Biagioni AF, Coimbra NC
Dissociation between the panicolytic effect of cannabidiol microinjected into the substantia nigra, pars reticulata, and fear-induced antinociception elicited by bicuculline administration in deep layers of the superior colliculus: The role of CB1-cannabinoid receptor in the ventral mesencephalon.
Eur J Pharmacol. 2015 Jul 5;758:153-63
da Silva JA, Biagioni AF, Almada RC, de Souza Crippa JA, Cecílio Hallak JE, Zuardi AW, Coimbra NC.
Recruitment of striatonigral disinhibitory and nigrotectal inhibitory GABAergic pathways during the organization of defensive behavior by mice in a dangerous environment with the venomous snake Bothrops alternatus (Reptilia, Viperidae).
Involvement of prelimbic medial prefrontal cortex in panic-like elaborated defensive behaviour and innate fear-induced antinociception elicited by GABAA receptor blockade in the dorsomedial and ventromedial hypothalamic nuclei: role of the endocannabinoid CB1 receptor.
Int J Neuropsychopharmacol. 2013 Sep;16(8):1781-98
Freitas RL, Salgado-Rohner CJ, Hallak JE, Crippa JA, Coimbra NC.
NMDA and AMPA/kainate glutamatergic receptors in the prelimbic medial prefrontal cortex modulate the elaborated defensive behavior and innate fear-induced antinociception elicited by GABAA receptor blockade in the medial hypothalamus.
Cereb Cortex. 2014 Jun;24(6):1518-28
de Freitas RL, Salgado-Rohner CJ, Biagioni AF, Medeiros P, Hallak JE, Crippa JA, Coimbra NC.
Serotonergic neural links from the dorsal raphe nucleus modulate defensive behaviours organised by the dorsomedial hypothalamus and the elaboration of fear-induced antinociception via locus coeruleus pathways.
Neuropharmacology. 2013 Apr;67:379-94
Biagioni AF, de Freitas RL, da Silva JA, de Oliveira RC, de Oliveira R, Alves VM, Coimbra NC.
Anti-aversive effects of cannabidiol on innate fear-induced behaviors evoked by an ethological model of panic attacks based on a prey vs the wild snake Epicrates cenchria crassus confrontation paradigm.
Neuropsychopharmacology. 2012 Jan;37(2):412-21
Uribe-Mariño A, Francisco A, Castiblanco-Urbina MA, Twardowschy A, Salgado-Rohner CJ, Crippa JA, Hallak JE, Zuardi AW, Coimbra NC.
Paradoxical effect of noradrenaline-mediated neurotransmission in the antinociceptive phenomenon that accompanies tonic-clonic seizures: role of locus coeruleus neurons and α(2)- and β-noradrenergic receptors.
Epilepsy Behav. 2011 Oct;22(2):165-77
Felippotti TT, dos Reis Ferreira CM, de Freitas RL, de Oliveira RC, de Oliveira R, Paschoalin-Maurin T, Coimbra NC.