Physiol Behav. 2018 Jul 10;194:538-544.

Restricted lesions of the ventrolateral or dorsal columns of the periaqueductal gray promotes distinct effects on tonic immobility and defensive analgesia in guinea pigs.

Vieira-Rasteli EB, de Paula BB, de Paiva YB, Coimbra NC, Leite-Panissi CRA.

J Neurosurg. 2018 Jun 8:1-14.

A new model of experimental hemispherotomy in young adult Rattus norvegicus: a neural tract tracing and SPECT in vivo study.

Matias I Jr, Elias-Filho DH, Garcia CAB, Silva GH, Mejia J, Cabral FR, Miranda ACC, da Silva SG, da Silva Lopes L, Coimbra NC, Machado HR.

Front Neural Circuits. 2018 May 7;12:36.

Stimulation of the Nigrotectal Pathway at the Level of the Superior Colliculus Reduces Threat Recognition and Causes a Shift From Avoidance to Approach Behavior.

Almada RC, Genewsky AJ, Heinz DE, Kaplick PM, Coimbra NC, Wotjak CT.

Neuroscience. 2018 Jul 15;383:191-204.

Brain Stimulation Differentially Modulates Nociception and Inflammation in Aversive and Non-aversive Behavioral Conditions.

Bassi GS, Kanashiro A, Rodrigues GJ, Cunha FQ, Coimbra NC, Ulloa L.

Physiol Behav. 2018 May 12;194:162-169

Neurotoxic lesions of the pedunculopontine tegmental nucleus impair the elaboration of postictal antinociception.

de Oliveira RC, de Oliveira R, Falconi-Sobrinho LL, Biagioni AF, Almada RC, Dos Anjos-Garcia T, Bazaglia-de-Sousa G, Khan AU, Coimbra NC.

J Psychopharmacol. 2018 Jun;32(6):711-722

The Nitric Oxide Donor SIN-1-Produced Panic-Like Behaviour And Fear-Induced Antinociception Are Modulated By NMDA Receptors In The Anterior Hypothalamus.

Falconi-Sobrinho LL, Coimbra NC.

Neuroscience. 2018 Jan 15;369:336-349

The Rodent-versus-wild Snake Paradigm as a Model for Studying Anxiety- and Panic-like Behaviors: Face, Construct and Predictive Validities.

Paschoalin-Maurin T, Dos Anjos-Garcia T, Falconi-Sobrinho LL, de Freitas RL, Coimbra JPC, Laure CJ, Coimbra NC

Eur Neuropsychopharmacol. 2017 Nov;27(11):1120-1131.

Decrease in NMDA receptor-signalling activity in the anterior cingulate cortex diminishes defensive behaviour and unconditioned fear-induced antinociception elicited by GABAergic tonic inhibition impairment in the posterior hypothalamus.

Falconi-Sobrinho LL, Anjos-Garcia TD, de Oliveira R, Coimbra NC

Psychopharmacology (Berl). 2017 Aug 30

Panicolytic-like effects caused by substantia nigra pars reticulata pretreatment with low doses of endomorphin-1 and high doses of CTOP or the NOP receptors antagonist JTC-801 in male Rattus norvegicus.

da Silva JA, Biagioni AF, Almada RC, de Freitas RL, Coimbra NC

Behav Brain Res. 2017 Jul 21

5-Hydroxytryptamine 2A receptors of the dorsal raphe nucleus modulate panic-like behaviours and mediate fear-induced antinociception elicited by neuronal activation in the central nucleus of the inferior colliculus.

da Silva Soares R Jr, Falconi-Sobrinho LL, Dos Anjos-Garcia T, Coimbra NC

J Psychopharmacol. 2017 Jun;31(6):715-721

μ-Opioid and 5-HT1A receptors in the dorsomedial hypothalamus interact for the regulation of panic-related defensive responses.

Roncon CM, Yamashita PSM, Frias AT, Audi EA, Graeff FG, Coimbra NC, Zangrossi H

Neuroscience. 2017 Jun 23;354:178-195

Opioid neurotransmission modulates defensive behavior and fear-induced antinociception in dangerous environments.

Coimbra NC, Calvo F, Almada RC, Freitas RL, Paschoalin-Maurin T, Dos Anjos-Garcia T, Elias-Filho DH, Ubiali WA, Lobão-Soares B, Tracey I

Rev Bras Psiquiatr. 2017 Jan-Mar;39(1):72-83

Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests.

Coimbra NC, Paschoalin-Maurin T, Bassi GS, Kanashiro A, Biagioni AF, Felippotti TT, Elias-Filho DH, Mendes-Gomes J, Cysne-Coimbra JP, Almada RC, Lobão-Soares B.

Behav Brain Res. 2017 Feb 15;319:135-147

Connexions between the dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal grey matter are critical in the elaboration of hypothalamically mediated panic-like behaviour.

Ullah F, Dos Anjos-Garcia T, Mendes-Gomes J, Elias-Filho DH, Falconi-Sobrinho LL, Freitas RL, Khan AU, Oliveira R, Coimbra NC

Neuropharmacology. 2017 Feb;113(Pt A):367-385

Unravelling cortico-hypothalamic pathways regulating unconditioned fear-induced antinociception and defensive behaviours.

Falconi-Sobrinho LL, Anjos-Garcia TD, Elias-Filho DH, Coimbra NC

Neuropharmacology. 2016 Apr 7. pii: S0028-3908(16)30139-3

CB1 cannabinoid receptor-mediated anandamide signalling reduces the defensive behaviour evoked through GABAA receptor blockade in the dorsomedial division of the ventromedial hypothalamus

Dos Anjos-Garcia T, Ullah F, Falconi-Sobrinho LL, Coimbra NC

Eur Neuropsychopharmacol. 2015 Dec 21. pii: S0924-977X(15)00415-0

5-Hydroxytryptamine 1A receptors in the dorsomedial hypothalamus connected to dorsal raphe nucleus inputs modulate defensive behaviours and mediate innate fear-induced antinociception

Biagioni AF, de Oliveira RC, de Oliveira R, da Silva JA, Anjos-Garcia TD, Roncon CM, Corrado AP, Zangrossi H Jr, Coimbra NC

Brain Res. 2015 Nov 24. pii: S0006-8993(15)00858-6

Dorsal raphe nucleus acetylcholine-mediated neurotransmission modulates post-ictal antinociception: The role of muscarinic and nicotinic cholinergic receptors

de Oliveira RC, de Oliveira R, Biagioni AF, Falconi-Sobrinho LL, Coimbra NC

Behav Brain Res. 2015 Nov 3;298(Pt B):65-77

Neuroethological validation of an experimental apparatus to evaluate oriented and non-oriented escape behaviours: Comparison between the polygonal arena with a burrow and the circular enclosure of an open-field test

Biagioni AF, Anjos-Garcia TD, Ullah F, Fisher IR, Falconi-Sobrinho LL, Freitas RL, Felippotti TT, Coimbra NC

Neuropharmacology. 2015 Dec;99:620-6

Pharmacological evidence for the mediation of the panicolytic effect of fluoxetine by dorsal periaqueductal gray matter μ-opioid receptors

Roncon CM, Almada RC, Maraschin JC, Audi EA, Zangrossi H Jr, Graeff FG, Coimbra NC

Behav Brain Res. 2015 Oct 15;293:143-52

Relevance of dorsomedial hypothalamus, dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal gray matter in the organization of freezing or oriented and non-oriented escape emotional behaviors

Ullah F, dos Anjos-Garcia T, dos Santos IR, Biagioni AF, Coimbra NC

Neuroscience. 2015 Jun 30. pii: S0306-4522(15)00589-8.

Endocannabinoid signaling mechanisms in the substantia nigra pars reticulata modulate GABAergic nigrotectal pathways in mice threatened by urutu-cruzeiro venomous pit viper snake

Almada RC, Roncon CM, Elias-Filho DH, Coimbra NC.

Eur J Pharmacol. 2015 Jul 5;758:153-63

Dissociation between the panicolytic effect of cannabidiol microinjected into the substantia nigra, pars reticulata, and fear-induced antinociception elicited by bicuculline administration in deep layers of the superior colliculus: The role of CB1-cannabinoid receptor in the ventral mesencephalon.

da Silva JA, Biagioni AF, Almada RC, de Souza Crippa JA, Cecílio Hallak JE, Zuardi AW, Coimbra NC.

Synapse. 2015 Jun;69(6):299-313

Recruitment of striatonigral disinhibitory and nigrotectal inhibitory GABAergic pathways during the organization of defensive behavior by mice in a dangerous environment with the venomous snake Bothrops alternatus (Reptilia, Viperidae).

Almada RC, Coimbra NC

Neuroscience. 2015 Jan 22;284:988-97

Medial prefrontal cortex serotonergic and GABAergic mechanisms modulate the expression of contextual fear: intratelencephalic pathways and differential involvement of cortical subregions

Almada RC, Coimbra NC, Brandão ML

J Neurol Sci. 2014 Dec 15;347(1-2):82-9

Cannabidiol and endogenous opioid peptide-mediated mechanisms modulate antinociception induced by transcutaneous electrostimulation of the peripheral nervous system

Gonçalves TC, Londe AK, Albano RI, de Araújo Júnior AT, de Aguiar Azeredo M, Biagioni AF, Vasconcellos TH, Dos Reis Ferreira CM, Teixeira DG, de Souza Crippa JA, Vieira D, Coimbra NC

Brain Res. 2014 Aug 12;1576:35-42

Cortical thinning of the right anterior cingulate cortex in spider phobia: a magnetic resonance imaging and spectroscopy study.

Linares IM, Jackowski AP, Trzesniak CM, Arrais KC, Chagas MH, Sato JR, Santos AC, Hallak JE, Zuardi AW, Nardi AE, Coimbra NC, Crippa JA

Synapse. 2014 Aug;68(8):369-77

Intrinsic connections within the pedunculopontine tegmental nucleus are critical to the elaboration of post-ictal antinociception.

Mazzei-Silva EC, de Oliveira RC, dos Anjos Garcia T, Falconi-Sobrinho LL, Almada RC, Coimbra NC

J Psychopharmacol. 2013 Dec;27(12):1149-59

The role of 5-HT1A receptors in the anti-aversive effects of cannabidiol on panic attack-like behaviors evoked in the presence of the wild snake Epicrates cenchria crassus (Reptilia, Boidae).

Twardowschy A, Castiblanco-Urbina MA, Uribe-Mariño A, Biagioni AF, Salgado-Rohner CJ, Crippa JA, Coimbra NC

Synapse. 2014 Jan;68(1):16-30

The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT₂A and 5-HT₂C serotonergic receptors in post-ictal antinociception.

de Freitas RL, de Oliveira RC, de Oliveira R, Paschoalin-Maurin T, de Aguiar Corrêa FM, Coimbra NC

Brain Behav. 2013 May;3(3):286-301

Neuroanatomical and neuropharmacological approaches to postictal antinociception-related prosencephalic neurons: the role of muscarinic and nicotinic cholinergic receptors

de Freitas RL, Bolognesi LI, Twardowschy A, Corrêa FM, Sibson NR, Coimbra NC

J Psychopharmacol. 2013 Dec;27(12):1141-8

Cooperative regulation of anxiety and panic-related defensive behaviors in the rat periaqueductal grey matter by 5-HT1A and μ-receptors.

Roncon CM, Biesdorf C, Coimbra NC, Audi EA, Zangrossi H Jr, Graeff FG.

Int J Neuropsychopharmacol. 2013 Sep;16(8):1781-98

Involvement of prelimbic medial prefrontal cortex in panic-like elaborated defensive behaviour and innate fear-induced antinociception elicited by GABAA receptor blockade in the dorsomedial and ventromedial hypothalamic nuclei: role of the endocannabinoid CB1 receptor.

Freitas RL, Salgado-Rohner CJ, Hallak JE, Crippa JA, Coimbra NC.

Int J Radiat Biol. 2013 Aug;89(8):595-601

Neuropathology and behavioral impairments after bilateral global ischemia surgery and exposure to static magnetic field: Evidence in the motor cortex, the hippocampal CA1 region and the neostriatum.

Bertolino G, De Araujo FL, Souza HC, Coimbra NC, De Araujo JE.

Eur J Pharmacol. 2013 Jan 5;698(1-3):235-45

Chemical neuroanatomical and psychopharmacological evidence that κ receptor-mediated endogenous opioid peptide neurotransmission in the dorsal and ventral mesencephalon modulates panic-like behaviour.

da Silva JA, de Freitas RL, Eichenberger GC, Padovan CM, Coimbra NC.

Cereb Cortex. 2014 Jun;24(6):1518-28

NMDA and AMPA/kainate glutamatergic receptors in the prelimbic medial prefrontal cortex modulate the elaborated defensive behavior and innate fear-induced antinociception elicited by GABAA receptor blockade in the medial hypothalamus.

de Freitas RL, Salgado-Rohner CJ, Biagioni AF, Medeiros P, Hallak JE, Crippa JA, Coimbra NC.

Neurosci Lett. 2013 Feb 22;535:116-21

Rostral ventromedial medulla connections in Cavia porcellus and their relation with tonic immobility defensive behavior: a biotinylated dextran amine neurotracing study.

da Silva LF, Coimbra NC, Menescal-de-Oliveira L.

Neuropharmacology. 2013 Apr;67:379-94

Serotonergic neural links from the dorsal raphe nucleus modulate defensive behaviours organised by the dorsomedial hypothalamus and the elaboration of fear-induced antinociception via locus coeruleus pathways.

Biagioni AF, de Freitas RL, da Silva JA, de Oliveira RC, de Oliveira R, Alves VM, Coimbra NC.

Neuroscience. 2012 Dec 27;227:350-60

Differential involvement of dorsal raphe subnuclei in the regulation of anxiety- and panic-related defensive behaviors.

Spiacci A Jr, Coimbra NC, Zangrossi H Jr.

Pflugers Arch. 2012 Aug;464(2):155-66

Periaqueductal gray matter modulates the hypercapnic ventilatory response.

Lopes LT, Patrone LG, Bícego KC, Coimbra NC, Gargaglioni LH.

Behav Brain Res. 2012 Aug 1;233(2):422-7

Rostral ventromedial medulla modulates nociception and tonic immobility behavior through connections with the A7 catecholaminergic region.

da Silva LF, Coimbra NC, Menescal-de-Oliveira L.

Braz J Med Biol Res. 2012 Apr;45(4):328-36

Panic-like defensive behavior but not fear-induced antinociception is differently organized by dorsomedial and posterior hypothalamic nuclei of Rattus norvegicus (Rodentia, Muridae).

Biagioni AF, Silva JA, Coimbra NC.

Pharmacol Biochem Behav. 2012 Apr;101(2):265-70

Antinociception induced by acute oral administration of sweet substance in young and adult rodents: the role of endogenous opioid peptides chemical mediators and μ(1)-opioid receptors.

de Freitas RL, Kübler JM, Elias-Filho DH, Coimbra NC.

Neuropeptides. 2012 Feb;46(1):39-47

Endogenous opioid peptide-mediated neurotransmission in central and pericentral nuclei of the inferior colliculus recruits μ1-opioid receptor to modulate post-ictal antinociception.

Felippotti TT, de Freitas RL, Coimbra NC.

Basic Clin Pharmacol Toxicol. 2012 Apr;110(4):359-69

Lipopolysaccharide-induced sickness behaviour evaluated in different models of anxiety and innate fear in rats.

Bassi GS, Kanashiro A, Santin FM, de Souza GE, Nobre MJ, Coimbra NC.

Neuropsychopharmacology. 2012 Jan;37(2):412-21

Anti-aversive effects of cannabidiol on innate fear-induced behaviors evoked by an ethological model of panic attacks based on a prey vs the wild snake Epicrates cenchria crassus confrontation paradigm.

Uribe-Mariño A, Francisco A, Castiblanco-Urbina MA, Twardowschy A, Salgado-Rohner CJ, Crippa JA, Hallak JE, Zuardi AW, Coimbra NC.

J Neurol Sci. 2012 Jan 15;312(1-2):73-8

Neuropathology and behavioral impairments after three types of global ischemia surgery in Meriones unguiculatus: evidence in motor cortex, hippocampal CA1 region and the neostriatum.

Uribe-Mariño A, Francisco A, Castiblanco-Urbina MA, Twardowschy A, Salgado-Rohner CJ, Crippa JA, Hallak JE, Zuardi AW, Coimbra NC.

Epilepsy Behav. 2011 Oct;22(2):178-85

Acetylcholine-mediated neurotransmission within the nucleus raphe magnus exerts a key role in the organization of both interictal and postictal antinociception.

de Oliveira RC, de Oliveira R, Zanandréa PC, Paschoalin-Maurin T, Coimbra NC.

Epilepsy Behav. 2011 Oct;22(2):165-77

Paradoxical effect of noradrenaline-mediated neurotransmission in the antinociceptive phenomenon that accompanies tonic-clonic seizures: role of locus coeruleus neurons and α(2)- and β-noradrenergic receptors.

Felippotti TT, dos Reis Ferreira CM, de Freitas RL, de Oliveira RC, de Oliveira R, Paschoalin-Maurin T, Coimbra NC.

Nanomedicine. 2011 Dec;7(6):871-80

Effect of a nanostructured dendrimer-naloxonazine complex on endogenous opioid peptides μ1 receptor-mediated post-ictal antinociception.

Felippotti TT, do Carmo DR, Paim LL, Stradiotto NR, Bicalho Ude O, Parada CA, Grillo R, Fraceto LF, Coimbra NC.

Brain Res. 2010 Aug 19;1349:41-7

Glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus can modulate haloperidol-induced catalepsy.

Melo LL, Santos P, Medeiros P, Mello RO, Ferrari EA, Brandão ML, Maisonnette SS, Francisco A, Coimbra NC.

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